Why do ivf fail

This will greatly affect her chances of pregnancy with and without IVF. Older women are more likely to have a greater chance of IVF success when using donor eggs. For women over 37, or for those with high follicle-stimulating hormone levels, producing enough eggs may be difficult. If this is the case for you, the chances are that IVF will fail.

Someone will work with you to evaluate the chances of this happening and will discuss any changes that will need to be made to your fertility medications. Embryos that have chromosomal abnormalities can result in IVF failure, whether they are naturally conceived or developed in a lab. Chromosomal abnormalities are often the reason behind miscarriages and implantation failure during IVF.

You will probably be asked to quit smoking up to three months before the start of your IVF treatment. Smokers often need up to twice as many IVF cycles to conceive and are more likely to experience a miscarriage. If you are overweight or underweight, you should try and reach a healthy weight to increase chances of a successful IVF treatment. Abnormalities in the sperm may lead to an unfertilized egg.

There are three major roles of a sperm: to reach the egg through the fallopian tube, penetrate through the outer membrane of the egg and release half of its genetic material or the sperm DNA to produce an embryo.

So it is important to select the best quality sperm under high magnification during IVF for successful fertilization. Sometimes even a high-quality sperm that is chromosomally normal may lack enzymes required to break through the zona pellucida or the outer shell of the egg. Low quality, morphologically abnormal and less motile sperm may not be able to reach the egg to fertilize it.

Embryo selection plays a crucial role in a successful implantation. It is a natural function of the uterus to reject the embryos that are abnormal. This means the chromosomally abnormal embryo cannot survive and it results in implantation failure or miscarriage. So, an investigation of embryo health is important for a successful pregnancy.

A successful implantation also depends on the endometrial environment. There are various structural, hormonal and immunological factors that affect an ideal uterine environment. Structural uterine factors such as the abnormal shape of uterus, fibroids, polyps, scarring, difficult cervix and intrauterine adhesions can lead to an implantation failure.

Other main uterine issue includes a thin endometrium due to an early rise in the progesterone prior to the egg retrieval in an IVF cycle. Both paternal and maternal health matters in the success of an IVF pregnancy.

Consumption of alcohol, smoking, and drugs can lead to lots of complications during implantation and pregnancy. Improper management of systematic diseases like diabetes and hypertension and an unhealthy body weight also results in IVF failures.

Autoimmune disorders such as antiphospholipid syndrome and blood clotting disorders can lead to miscarriages. The embryo transfer is a non surgical procedure and is very sensitive. Any alteration in this procedure may lead to the failure of an IVF cycle. What went wrong? Should you try again? Chances are the failure is not due to anything you could control. Your fertility specialist will explain what may have happened and what you can do next.

Here are some common reasons why an IVF cycle fails. The major reason why an IVF cycle is not successful is embryo quality. Many embryos are not able to implant after transfer to the uterus because they are flawed in some way. Even embryos that look good in the lab may have defects that cause them to die instead of growing. This affects her chances of success with IVF as well.

On average, only about 25 percent of transferred embryos go on to result in live births of babies. Women under 35 using their own eggs for IVF have an implantation rate of about 45 percent. Women 40 to 42 years old using their own eggs have only about a 15 percent chance of implantation. Older women who use donor eggs, which are donated by younger women, have success rates with IVF that are nearly the same as those of younger women.